Randomice
1387
30
6
An article in Nature: https://www.nature.com/articles/s41586-026-10692-4
Jun 3, 2026 10:25 PM
Randomice
1387
30
6
An article in Nature: https://www.nature.com/articles/s41586-026-10692-4
redtails2649
Techno babble
SabottheHawk
New way to make hydrogen pumps inside chemical/biological reactions. Makes assembly of and bio availablity of easier. So can make special drugs cheaper and make them more effective.
duktayp
The tl;dr is: your body needs electrolytes
Unfortunate500
I can explain it to you, but I can't understand it for you.
L0rdinquisit0r
a new way to create chiral catalysts. they used to build molecules with specific "left-handed" or "right-handed" twist to the molecules. common sugar is "right handed", a left handed version cant be used as food so you get sweet but no calories. or the thalidomide problem, they tested the right handed version but the factory made the left hand version which has the infamous defect causing problem.
turbodog
Oh, I can explain it. Before I do, I just need to know: Does my explanation need to be correct and make sense? If so, yeah, no, I'm out.
0xBADA55
What are you dumb!? It’s pretty self explanatory .. right there .. in that abstract thingy
duktayp
Who is make thiis story haz a gud brain https://media2.giphy.com/media/v1.Y2lkPTZjMDliOTUyNXNxNWhwYzQyeHZmc3E3MGJjbHZ1ODJ0MmdlajhpczR4Y2s1MWNmbCZlcD12MV9pbnRlcm5hbF9naWZfYnlfaWQmY3Q9Zw/Lz4hiUMMtVK12/giphy.gif
dreikommavierzehn
Why the 'challenge'? What do you want to know specifically and what's your level of understanding?
If you know the advanced chemistry terms, you can just open up that paper and read the definitions. They will either explain or refer to a source for most of the terms. In fact the first two sentences and the last three tell you what it's about.
If you don't know the terms I'm not sure what we're here to talk about. A paper like this is way too specific. Tl;dr: It's about medicine development
dreikommavierzehn
If it helps, this paper writes about a specific process (explained in the abstract: HAT). They start by saying that traditional methods, that introduce a certain molecule to achieve that process are not good enough. They claim that their approach can produce such a molecule right where the drug process is supposed to work, and that this process has more precision and 'lifetime' (how long this part of the drug works, i.e. how much of the agent is needed for it).
dreikommavierzehn
Ah right, one bump to trip over is the little note of 'de novo' and 'in situ' because those terms can mean different things depending on context. Here they most likely (I'm not a pharma chemist) mean with 'de novo designs' molecules that have been specifically designed by chemists for this. Which then needs to be delivered to the body in a drug.
Whereas they show a way how make a suitable molecule 'in situ', that is in the body where the drug (or part of it) is supposed to work
usernametakenisthestoryofmylife
You lost me at Enant.
HonHomes
"We want to do some cool shit by fiddling with biology on a sub-cellular/molecular level, but catalysts (things that make reactions faster/easier) for this thing are kinda clumsy. We're figuring out a way around that by putting the catalyst together exactly where we need it"
I think. I am very sleepy, may have misread...
GratuaCuun
https://media1.giphy.com/media/v1.Y2lkPWE1NzM3M2U1OHp5NXJqY2Q3ODRqZG02ZXIxMnFudmZ2NmtqamF4M294eTc1dGZlbCZlcD12MV9naWZzX3NlYXJjaCZjdD1n/QBAZMF4pqkcJcSve71/200w.webp
Fiacre54
This isn’t really that magic. Anyone that’s taken organic chemistry understands chirality. There are a lot of jargon words in there, which scientist love to use. The important one is deracemization. It basically just means creating a solution of molecules that are arranged all the same way, instead of including some mirror image versions of it. The paper is detailing a way of making sure that when you do certain chemistry in solutions, you get all the same molecule rather than a mixture.
PineappleIsDeliciousOnPizzaFightMe
Ugh, OChem
Bystandr
A reaction pathway to create a specific left or right handed molecule utilizing a catalyst to transfer hydrogen via a non covalent bonded
Bystandr
molecule.
ParaspriteHugger
https://imgur.com/n3RZCFS.mp4
inire
Nature always goes one direction like nascar. But sometimes when we do this stuff we can make it go the other way. With this new catalyst it’s easier to make the other direction thingy.
ShutUpLoiosh
You first need to understand the Turbo Encabulator.
RetrogradeLlama
Now go take some ibuprofen before bed.
ShutUpLoiosh
As you wish.